Abstract: Taking A-share listed companies in Shanghai and Shenzhen from 2010 to 2019 as samples, the impact and role path of the changes of information disclosure regulatory model on audit quality were examined, while whether the professional expertise of auditors and key regulatory industries exhibit significant disparities in their impact on changes in information disclosure regulatory model with respect to audit quality was investigated. The study has found that after the changes of information disclosure regulatory model, the audit quality has significantly improved. The improvement of the accounting comparability and accounting conservatism are two important ways for the changes of information disclosure regulatory model to promote the improvement of audit quality. The professional expertise of auditors promotes the improvement of audit quality by the changes of information disclosure supervision mode. In key regulatory industries, the positive impact of changes in the regulatory model of information disclosure on audit quality is more significant. Therefore, promoting the expertise of the auditing industry and including more industries in the key regulatory list has a certain practical significance for the country to further promote the supervision of capital market information disclosure and optimize the market environment.