Abstract: To address the challenge of situation evolution caused by asynchronous emergence of multi-source public opinion information in public opinion crises, a dynamic response adjustment method integrating intuitionistic fuzzy sets (IFS) and regret theory was proposed. Firstly, IFS was employed to homogenize heterogeneous attribute data of public opinion information, and an intuitionistic fuzzy evaluation matrix considering information fuzziness and credibility was constructed, with attribute weight allocation optimized based on intuitionistic fuzzy entropy. Secondly, regret theory was introduced to calculate decision-makers’ perceived utility regarding the evolution of the crisis situation after plan implementation; subsequently, this utility was combined with perceived utilities concerning plan initiation and adjustment costs as well as response losses to compute the comprehensive perceived utility, thereby obtaining the priority order of alternative plans. Finally, the effectiveness of the proposed method was verified through case application and comparative analysis with other methods. The results show that the proposed method can effectively reflect the significant role of decision-makers’ regret-avoidance behavior characteristics and the evolution of public opinion crisis situations in the decision-making process of response plan adjustments, from the heterogeneous attribute level of public opinion information. The results demonstrate that the proposed method effectively reflects the critical role of decision-makers’ regret-aversion behavioral characteristics and the evolution of the public opinion crisis situation in response plan adjustment decisions from the heterogeneous attribute level of public opinion information. It is confirmed that simultaneously considering psychological behavioral characteristics (regret aversion) and crisis situation transition mechanisms significantly enhances decision-making scientificity and operational applicability. Furthermore, beyond the methodology developed based on heterogeneous attributes and their fusion of public opinion information, the competitive-cooperative structure in multi-source information dissemination and its impact on heterogeneous attributes can be considered for establishing a situation updating mechanism and investigating adjustment timing. Simultaneously, the multi-stage sequencing, adjustment timing, and directional aspects of comprehensive response plans are explored from an event-chain perspective by examining interactions between public opinion crises and their precursor gradual-onset emergencies.