Abstract: SnO₂ nanomaterials were synthesized with hydrothermal method by using SnCl₄5H₂O and NH₃H₂O as raw materials, and nanomaterial modified electrodes were prepared. The experimental results show that the SnO₂ nanomaterial modified electrode has good electrocatalytic performance for dopamine electrochemical oxidation process. The effect of pH values, modification amount, sweep rate and other factors on the electrochemical behavior of dopamine were studied,the optimal experimental conditions were obtained and the detection of dopamine was achieved by differential pulse voltammetry. The results showed that the oxidation peak current and the dopamine concentration varied linearly in the concentration range of 1.0×10^-5-9.0×10^-5 mol/L, and the correlation coefficient can reach 0.991 4.