Abstract: It was assumed that the micro element failure of rock considering chemical corrosion obeyed the Weibull distribution after loading. Combined with the damage mechanics theory, considering the coupling effect of chemical corrosion and load and compaction, the corresponding segmental uniaxial damage constitutive model was established. The influence of chemical corrosion interaction on the stress-strain relationship of sandy slate was simulated and analyzed, and the uniaxial compression test results of sandy slate after different soaking time were used to verify. The results show that the simulation results are in good agreement with the experimental results, and the constitutive model can well reflect the prepeak stressstrain relationship of sandy slate under chemical corrosion, which is reasonableness and feasibility.