Abstract: In response to the problem of low leaching rate of indium from zinc indium ferrite through conventional acid leaching, the mechanical activation and microwave synergistic enhancement methods were used to extract indium from zinc indium ferrite through acid leaching. The lattice structure changes of zinc indium ferrite before and after mechanical activation were analyzed, and the influence of different process factors on the leaching behavior of indium from zinc indium ferrite was studied. The kinetics of indium leaching process under mechanical activation and microwave synergistic enhancement were also analyzed. The results show that after mechanical activation, the crystal structure of zinc indium ferrite is destroyed, the diffraction peak intensity decreases, the peak pattern widens, the grain size decreases, and the lattice strain increases. Under the conventional conditions, the highest indium leaching rate is only 59.2% at the low temperature and low acid conditions, and 92.0% (150 min) at the high temperature and high acid conditions. When microwave and mechanical activation act separately and synergistically, the promotion of indium leaching rate under low temperature and low acid conditions is not significant, while the leaching rate under high temperature and high acid conditions reaches 100%, and the time gradually decreases to 120, 90, and 60 min. The synergistic effect of mechanical activation and microwave significantly improves the efficiency of indium leaching. The kinetic process of indium leaching under the synergistic effect of mechanical activation microwave is more suitable for surface chemical reaction control models.