Synthesis of 4,7-Dimethylcoumarin and Its Potential Drug Target

To optimize reaction condition of 4,7-dimethylcoumarin synthesis and stimulate its potential target, taking m-cresol and ethyl acetoacetate as starting materials, dichloromethane as solvent, sulfuric acid as catalyst, 4, 7-dimethylcoumarin was synthesized by pechmann reaction.With the aid of software Discovery Studio, the potential drug target of the compound was stimulated. The preferred reaction condition was obtained by the orthogonal experiment, that is reaction temperature of 20℃,the mass ratio of sulfuric acid to m-cresol of 2.5, the volumeto-mass ratio of dichloromethane to m-cresol of 15 mL/g, the mole yield of reaction of 63.9%. And the potential drug target of the compound is problely glycogen synthetase kinase 3β.